Publications at Harvard
2024
5. Polpum Onnuch, Kranthikumar Ramagonolla, Richard Y. Liu. “Aminative Suzuki–Miyaura Coupling.” Science 2024, 383, 1019–1024. (link)
4. Dawei Xi, Abdulrahman M. Alfaraidi, Jinxu Gao, Thomas Cochard, Luana C. I. Faria, Zheng Yang, Thomas Y. George, Taobo Wang, Roy G. Gordon, Richard Y. Liu, Michael J. Aziz. “Mild pH-decoupling aqueous flow battery with practical pH recovery.” Nat. Energy 2024, 1–12. (link)
3. Kelvin J. Y. Wu, Ben I. C. Tresco, Antonio Ramkissoon, Elena V. Aleksandrova, Egor A. Syroegin, Dominic N. Y. See, Priscilla Liow, Georgia A. Dittemore, Meiyi Yu, Giambattisa Testolin, Matthew J. Mitcheltree, Richard Y. Liu, Maxim S. Svetlov, Yury S. Polikanov, Andrew G. Myers. “An Antibiotic Preorganized for Ribosomal Binding Overcomes Antimicrobial Resistance.” Science 2024, 383, 721–726. (link)
2023
2. Abdulrahman M. Alfaraidi, Dawei Xi, Nina Ni, Thomas Y. George, Tatsuhiro Tsukamoto, Roy G. Gordon, Michael J. Aziz, Richard Y. Liu. “An Extremely Stable and Soluble NH2-Substituted Anthraquinone Electrolyte for Aqueous Redox Flow Batteries.” ACS Appl. Energy Mater. 2023, 6, 12259–12266. (link)
1. Abdulrahman M. Alfaraidi, Bryan Kudisch, Nina Ni, Jayden Thomas, Thomas Y. George, Khashayar Rajabimoghadam, Haihui Joy Jiang, Daniel G. Nocera, Michael J. Aziz, Richard Y. Liu. “Reversible CO2 Capture and On-Demand Release by an Acidity-Matched Organic Photoswitch.” J. Am. Chem. Soc. 2023, 145, 26720–26727. (link)
Prior Work
27. Richard Y. Liu, Shao-Xiong Lennon Luo, Elizabeth S. Hirst, Christopher J. Doona, Timothy M. Swager. “Bifunctional Diazirine Reagent for Covalent Dyeing of Kevlar and Inert Polymer Materials.” Polym. Chem. 2023, 14, 4205-4215 (link)
26. Anthony J. Rojas, Justin M. Wolfe, Heemal H. Dhanjee, Ivan Buslov, Nicholas L. Truex, Richard Y. Liu, Walter Massefski, Bradley L. Pentelute, Stephen L. Buchwald. “Palladium–Peptide Oxidative Addition Complexes for Bioconjugation.” Chem. Sci. 2022, 13, 11891–11895. (link)
25. Richard Y. Liu*, Sheng Guo*, Shao-Xiong Lennon Luo, Timothy M. Swager. “Solution-Processable Microporous Polymer Platform for Heterogenization of Diverse Photoredox Catalysts.” Nat. Commun. 2022, 13, 1–8. (* denotes equal contribution.) (link)
24. Máté J. Bezdek, Shao-Xiong Lennon Luo, Richard Y. Liu, Qilin He, Timothy M. Swager. “Trace Hydrogen Sulfide Sensing Inspired by Polyoxometalate-Mediated Aerobic Oxidation.” ACS Cent. Sci. 2021, 7, 1572–1580. (link)
23. Shao-Xiong Lennon Luo, Richard Y. Liu, Sungsik Lee, Timothy M. Swager. “Electrocatalytic Isoxazoline–Nanocarbon Metal Complexes.” J. Am. Chem. Soc. 2021, 143, 10441–10453. (link)
22. Michael W. Gribble, Jr.‡, Richard Y. Liu‡, Stephen L. Buchwald. “Evidence for Simultaneous Dearomatization of Two Aromatic Rings under Mild Conditions in Cu(I)-Catalyzed Direct Asymmetric Dearomatization of Pyridine.” J. Am. Chem. Soc. 2020, 142, 11252–11269. (‡ denotes corresponding author.) (link)
21. Richard Y. Liu, Stephen L. Buchwald. “CuH-Catalyzed Hydrofunctionalization: From Hydroamination to Carbonyl Addition.” Acc. Chem. Res. 2020, 53, 1229–1243. (link)
20. Richard Y. Liu*, Joseph M. Dennis*, Stephen L. Buchwald. “The Quest for the Ideal Base: Rational Design of a Nickel Precatalyst Enables Mild, Homogeneous C–N Cross-Coupling.” J. Am. Chem. Soc. 2020, 9, 4500–4507. (link)
19. Chengxi Li*, Kwangmin Shin*, Richard Y. Liu, Stephen L. Buchwald. “Engaging Aldehydes in CuH-Catalyzed Reductive Coupling Reactions: Stereoselective Allylation from 1,3-Diene Pronucleophiles.”
Angew. Chem. Int. Ed. 2020, 58, 17074–17080. (* denotes equal contribution.) (link)
18. Jessica Xu, Richard Y. Liu, Charles S. Yeung, Stephen L. Buchwald. “Monophosphine Ligands Promote Pd-Catalyzed C–S Cross-Coupling Reactions at Room Temperature with Soluble Bases.” ACS Catal. 2019, 9, 6461–6466. (link)
17. Chengxi Li, Richard Y. Liu, Luke T. Jesikiewicz, Yang Yang, Peng Liu, Stephen L. Buchwald. “CuH-Catalyzed Regio- and Enantioselective Ketone Allylation with 1,3-Dienes: Scope, Mechanism, and Applications.” J. Am. Chem. Soc. 2019, 141, 5062–5070. (link)
16. Joseph M. Dennis, Nicholas A. White, Richard Y. Liu, Stephen L. Buchwald. “Pd-Catalyzed C–N Coupling Reactions Facilitated by Amine Bases: Mechanistic Investigation Leads to Enhanced Reactivity in the Arylation of Weakly Binding Amines.” ACS Catal. 2019, 9, 3822–3830. (link)
15. Richard Y. Liu*, Yujing Zhou*, Yang Yang, Stephen L. Buchwald. “Enantioselective Allylation from Allene, a Petroleum Cracking Byproduct.” J. Am. Chem. Soc. 2019, 141, 2251–2256. (* denotes equal contribution.) (link)
14. Joseph M. Dennis*, Nicholas A. White*, Richard Y. Liu, Stephen L. Buchwald. “Breaking the Base Barrier: An Electron-Deficient Palladium Catalyst Enables the Use of Amine Bases in C–N Coupling.” J. Am. Chem. Soc. 2018, 140, 4721–4725. (* denotes equal contribution.) (link)
13. Richard Y. Liu and Stephen L. Buchwald. “Copper-Catalyzed Enantioselective Hydroamination of Alkenes.” Org. Synth. 2018, 95, 80–96. (Invited submission to Organic Syntheses.) (link)
12. Erica Y. Tsai, Richard Y. Liu, Yang Yang, Stephen L. Buchwald. “A Regio- and Enantioselective CuH-Catalyzed Ketone Allylation with Terminal Allenes.” J. Am. Chem. Soc. 2018, 140, 2007–2011. (link)
11. Richard Y. Liu*, Minwoo Bae*, Stephen L. Buchwald. “Mechanistic Insight Facilitates Discovery of a Mild and Efficient Copper-Catalyzed Dehydration of Primary Amides to Nitriles Using Hydrosilanes.” J. Am. Chem. Soc. 2018, 140, 1627–1631. (* denotes equal contribution.) (link)
10. Yujing Zhou, Jeffrey S. Bandar, Richard Y. Liu, Stephen L. Buchwald. “CuH-Catalyzed Asymmetric Reduction of α,β-Unsaturated Carboxylic Acids to β-Chiral Aldehydes.” J. Am. Chem. Soc. 2018, 140, 606–609. (link)
9. Gang Lu, Richard Y. Liu, Yang Yang, Cheng Fang, Daniel S. Lambrecht, Stephen L. Buchwald, Peng Liu. “Ligand–Substrate Dispersion Facilitates the Copper-Catalyzed Hydroamination of Unactivated Olefins.” J. Am. Chem. Soc. 2017, 139, 16548–16555. (link)
8. Yongho Park, Kaid C. Harper, Nadine Kuhl, Eugene E. Kwan, Richard Y. Liu, Eric N. Jacobsen. “Macrocyclic Bis-Thioureas Catalyze Stereospecific Glycosylation Reactions.” Science 2017, 355, 162–166. (link)
7. Michael W. Gribble, Jr., Michael T. Pirnot, Jeffrey S. Bandar, Richard Y. Liu, Stephen L. Buchwald. “Asymmetric Copper Hydride-Catalyzed Markovnikov Hydrosilylation of Vinylarenes and Vinyl Heterocycles.” J. Am. Chem. Soc. 2017, 139, 2192–2195. (link)
6. Richard Y. Liu, Yang Yang, Stephen L. Buchwald. “Regiodivergent and Diastereoselective CuH-Catalyzed Allylation of Imines with Terminal Allenes.” Angew. Chem. Int. Ed. 2016, 55, 14077–14080. (link)
5. Benjamin H. Rotstein, Lu Wang, Richard Y. Liu, Jon Patteson, Eugene E. Kwan, Neil Vasdev, Steven H. Liang. “Mechanistic Studies and Radiofluorination of Structurally Diverse Pharmaceuticals with Spirocyclic Iodonium(III) Ylides.” Chem. Sci. 2016, 7, 4407–4417. (link)
4. Eugene E. Kwan, Richard Y. Liu. “Enhancing NMR Prediction for Organic Compounds Using Molecular Dynamics.” J. Chem. Theory Comput. 2015, 11, 5083–5089. (link)
3. Richard Y. Liu, Masayuki Wasa, Eric N. Jacobsen. “Enantioselective Synthesis of Tertiary α-Chloro Esters by Non-Covalent Catalysis.” Tetrahedron Lett. 2014, 56, 3428–3430. (Invited submission in honor of Harry H. Wasserman.) (link)
2. Masayuki Wasa, Richard Y. Liu, Stéphane P. Roche, Eric N. Jacobsen. “Asymmetric Mannich Synthesis of α-Amino Esters by Anion-Binding Catalysis.” J. Am. Chem. Soc. 2014, 136, 12872–12875. (link)
1. Elisabeth T. Hennessey, Richard Y. Liu, Diana A. Iovan, Ryan A. Duncan, Theodore A. Betley. “Iron-Mediated Intermolecular N-Group Transfer Chemistry with Olefinic Substrates.” Chem. Sci. 2014, 5, 1526–1532. (link)